A Study on the Biochemical and the Morphological Changes in the Liver in
Renal Transplant Recipients with an
Evidence of the HBV and the
HCV Infections
Published: January 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.2675
Sonia Sharma, Anshu Gupta, Shivani Kalhan, Sharmila Dudani, Pankaj Sharma, Amit Devra
1. Assisstant Professor, Department of Pathology,
Army College of Medical Sciences, Delhi Cantt, India.
2. Associate Professor, Department of Pathology, Saraswathi
Instt of Medical Sciences, Anwarpur, Hapur(UP), India.
3. Professor, Department of Pathology, Saraswathi Instt of
Medical Sciences, Anwarpur, Hapur(UP), India.
4. Assistant Professor, Department of Pathology, Army
College of Medical Sciences, Delhi Cantt. India.
5. Department of Radiology, Army Hospital R&R,
Delhi Cantt, India.
6. DNB (Urology), Consultant Urologist and Transplant
Surgeon Pushpawati Singhania Research Instt, Sheikh
Sarai, New Delhi, India.
Correspondence
Dr. Anshu Gupta,
Associate Professor, Department of Pathology,
R- 13/27, Raj Nagar, Ghaziabad-201002,U.P.,India.
Phone: 9985199756
E-mail: amitanshu75@gmail.com
Context: Renal transplantation is the definitive treatment in renal failure patients. Liver disease is a known problem in renal transplant recipients. They may be consequent to immunosuppression, drug toxicity, altered immune response to viruses and hemodialysis.
Aims: The aim of this study was to analyze and correlate the biochemical parameters and histopathology of liver biopsy among renal transplant recipients with both HBV and HCV infection and to correlate them.
Setting: The study group had thirty cases. Enrolment criteria included coinfection with HBV and HCV ; elevated liver enzymes and recipient of renal allograft. There was acontrol group of ten patients who were HBC and HCV positive but had not undergone renal transplant.
Material & Methods: Liver function tests including alkaline phosphatase, SGOT, SGPT and serum bilirubin levels were donet. Percutaneous liver biopsies were carried out using Menghini’s needle.. Stains done included hematoxylin and eosin (H & E), vanGieson, reticulin and Perl’s stain. Histopathological grading was performed using Metavir scoring system. Immunohistochemistry (IHC) was done where required for ground glass hepatocytes. Correlation of SGOT, SGPT and Alkaline phosphatase of the study group and the controls was carried out with the grading. Statistical Analysis: Statistical tests done included paired “t” test at 5% and test of probability.
Results: There was no statistically significant correlation between the controls and the transplanted patients. It was concluded that serum enzyme levels could be used to predict histological grade in the control group but not in the transplant recipients (p>0.05).
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